Tessera Therapeutics is a Gene & Genome Editing Platforms company founded in 2018 and based in Somerville, United States. It has raised $530M in total funding, most recently a Series C in 2022.

Biotechs race to develop gene-editing cures for alpha-1 antitrypsin deficiency, with competing technologies and a U.S.-China rivalry.
Tessera's Gene Writing technology re-engineers mobile genetic elements — naturally occurring systems that copy and relocate DNA and RNA within genomes — into programmable tools for installing therapeutic genetic changes. Unlike CRISPR, which primarily cuts DNA, Gene Writers are designed to write new sequence directly, spanning single-nucleotide corrections, short insertions and deletions, and the insertion of entire genes. Tessera pairs the platform with lipid-nanoparticle delivery for in vivo administration, and has reported proof-of-concept data in non-human primates across its Gene Writing and delivery platforms.
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