Minicircle
Minicircle is a Gene Therapy company founded in 2020 and based in Austin, United States.
Minicircle is an Austin-based biotech founded in 2020 by Mac Davis and Walter Patterson that develops minicircle DNA plasmid gene therapies designed to produce transient, non-heritable expression of proteins like follistatin (a myostatin inhibitor associated with muscle growth and reduced body fat) and klotho (associated with aging biology). Therapies are administered through licensed clinicians at independent partner clinics in Próspera ZEDE, Honduras and other jurisdictions outside FDA review, on a patient-pays basis. The company has attracted backing from longevity and crypto-aligned investors including Founders Fund, Adam Neumann's Flow, Balaji Srinivasan, Sam Altman and Peter Thiel, and gained public attention through high-profile self-experimenters such as Bryan Johnson.
Minicircle is the highest-profile test case for offshoring early-stage gene therapy outside FDA jurisdiction and selling it directly to patients — an unconventional regulatory and commercial model that, if it scales, could redraw the boundary between investigational biotech and the consumer longevity market.
minicircle.io ↗·Gene Therapy·
United States·private 
