BioAge Labs (NASDAQ: BIOA) is a publicly traded Aging Drug Discovery company founded in 2015 and based in Richmond, United States.
| Date | Stage | Amount | Valuation | Lead investors |
|---|---|---|---|---|
| Sep 26, 2024 | IPO (Nasdaq: BIOA) | $198M | — | — |
| Feb 13, 2024 | Series D | $170M | — | Sofinnova Investments |
BioAge Labs reported Q2 2026 results with flat collaboration revenue of $2.451 million year-over-year. R&D expenses rose 23% to $24.4 million, primarily driven by $7.9 million in increased direct costs for the BGE-102 program as QUELL-CV Phase 2 trial initiation and QUELL-DME start-up costs. Net loss widened to $26.1 million ($0.58 per share) from $21.6 million ($0.60 per share) in Q2 2025. Operationally, the company dosed the first patient in QUELL-CV, a Phase 2 dose-ranging trial in obesity with inflammation, expecting topline data in H2 2026. QUELL-DME, a Phase 1b/2a trial in diabetic macular edema, is planned to initiate mid-2026 with data expected mid-2027. BGE-102 Phase 1 data showed up to 98% IL-1 suppression and 86% hsCRP reductions. Cash position stood at $381.3 million, funding operations through 2029. The company also plans to file its first APJ agonist IND by year-end 2026.
Topline QUELL-CV data anticipated H2 2026; QUELL-DME data anticipated mid-2027; first APJ agonist IND filing planned by year-end 2026
BioAge's lead drug candidate, a potent, orally available, brain-penetrant small-molecule NLRP3 inhibitor with a structurally novel chemotype and binding site. NLRP3 is a central driver of age-related inflammation implicated in cardiovascular, metabolic, neurodegenerative and retinal disease, and BioAge's human-aging analyses linked reduced NLRP3 activity to greater longevity. In Phase 1, BGE-102 produced potential best-in-class reductions in high-sensitivity C-reactive protein (hsCRP) and 90-98% suppression of IL-1Beta with a favorable tolerability profile. The company plans a Phase 1b/2a proof-of-concept trial in diabetic macular edema in mid-2026.
BioAge's core engine analyzes molecular and clinical data from large human aging cohorts, including longitudinal blood samples, to identify pathways and targets associated with healthy aging and longevity. By grounding target selection in human rather than purely model-organism biology, the platform aims to de-risk drug discovery for age-related diseases such as metabolic and inflammatory conditions. It nominated NLRP3 as a target behind lead candidate BGE-102 and continues to generate the company's broader pipeline spanning metabolic-aging and immuno-aging programs.
5 patents on file, but none with both an extractable figure and an abstract on Google Patents yet.