Generate Biomedicines (NASDAQ: GENB) is a publicly traded AI Protein & Enzyme Design company founded in 2018 and based in Somerville, United States.
| Date | Stage | Amount | Valuation | Lead investors |
|---|---|---|---|---|
| Feb 26, 2026 | IPO (Nasdaq: GBIO) | $400M | — | — |
| Sep 14, 2023 | Series C | $273M | — | Flagship Pioneering, Amgen, NVentures |
Generate Biomedicines reported Q2 2026 collaboration revenue of $6.3 million, down 38% year-over-year from $10.1 million in Q2 2025, reflecting ongoing Amgen and Novartis research programs. Net loss widened to $67.3 million from $56.7 million in the prior-year quarter. R&D expenses increased to $64.3 million from $59.7 million, driven by expansion of GB-0895 Phase 3 SOLAIRIA asthma trials across six global regions; 33 of 42 target countries have approved the studies to date. GB-4362 (MMAE neutralizer) completed enrollment of its first Phase 1 cohort in urothelial cancer. Novartis advanced a biologic engineered via Generate's platform into preclinical development—the first time such an AI-enabled design has reached this stage. Cash and equivalents stood at $457.4 million as of June 30, sufficient for operations into H1 2028.
Cash expected to fund operations into H1 2028; additional capital required for long-term operations
The Generate Platform is the company's generative-biology engine for designing protein therapeutics. It uses generative AI, including the Chroma diffusion model for proteins, to create novel sequences and structures with desired properties rather than screening existing molecules. The platform runs a continuous generate-build-measure-learn loop that designs candidates, tests them in the lab, and feeds results back into the models, aiming to improve target specificity and cut the time and cost of finding therapeutic candidates across antibodies and other modalities.
GB-0895 is Generate Biomedicines' lead clinical program, an antibody designed on its generative platform that targets thymic stromal lymphopoietin (TSLP). The company is advancing GB-0895 into late-stage studies for severe asthma, with additional evaluation in chronic obstructive pulmonary disease (COPD). As the most mature asset to emerge from the Generate Platform, it serves as a key clinical test of whether AI-designed protein therapeutics can match or exceed conventionally discovered biologics in the clinic.
2 patents on file, but none with both an extractable figure and an abstract on Google Patents yet.
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